The chromogranin-secretogranin family.
نویسندگان
چکیده
From the Department of Medicine (L.T., K.L.H., D.T.O.) and the Center for Molecular Genetics (D.T.O.), University of California at San Diego, La Jolla; and the Veterans Affairs San Diego Healthcare System, San Diego, Calif. (L.T., K.L.H., D.T.O.). Address reprint requests to Dr. O’Connor at the Department of Medicine (9111H), University of California at San Diego, 3350 La Jolla Village Dr., San Diego, CA 92161, or at [email protected].
منابع مشابه
Chromogranin A processing and secretion: specific role of endogenous and exogenous prohormone convertases in the regulated secretory pathway.
Chromogranins A and B and secretogranin II are a family of acidic proteins found in neuroendocrine secretory vesicles; these proteins contain multiple potential cleavage sites for proteolytic processing by the mammalian subtilisin-like serine endoproteases PC1 and PC2 (prohormone convertases 1 and 2), and furin. We explored the role of these endoproteases in chromogranin processing in AtT-20 mo...
متن کاملChromogranin A in Physiology and Oncology ( chromogranin / neuroendocrine tumours / cleavage fragments / extracellular functions / intracellular functions / tumour marker )
Chromogranin A (CgA) is a hydrophilic acidic one-chain peptide containing 439 amino acids, preceded by NH 2 -terminal 18-amino-acid signal peptide; the complete pre-chromogranin A molecule thus encompasses 457 amino acids. It is a member of the chromogranin family that comprises several proteins. The CgA gene is a single-copy gene localized in the locus 14q32. Chromogranin A is produced by endo...
متن کاملAn antibody against secretogranin I (chromogranin B) is packaged into secretory granules
We have investigated the sorting and packaging of secretory proteins into secretory granules by an immunological approach. An mAb against secretogranin I (chromogranin B), a secretory protein costored with various peptide hormones and neuropeptides in secretory granules of many endocrine cells and neurons, was expressed by microinjection of its mRNA into the secretogranin I-producing cell line ...
متن کاملChromogranin a Positive Mast Cells in the Dog Paranal Sinus
The granin family (Chromogranin A (CgA), 4 Chromogranin B (CgB), Secretogranin (Sg) II, and the less well studied Secretogranins III-VII) comprises a group of acidic proteins that are present in the secretory granules of a wide variety of endocrine and neuro-endocrine cells [6, 22]. There is evidence that granins may be associated to the precursors of biologically active peptides [11, 12, 17]. ...
متن کاملChromogranins A and B and secretogranin II as prohormones for regulatory peptides from the diffuse neuroendocrine system.
Chromogranin A (CgA), chromogranin B (CgB), and secretogranin II (SgII) belong to a family of uniquely acidic secretory proteins in elements of the diffuse neuroendocrine system. These "granins" are characterized by numerous pairs of basic amino acids as potential sites for intra- and extragranular processing. In response to adequate stimuli, the granins are coreleased with neurotransmitters an...
متن کاملDecreased cerebrospinal fluid secretogranin II concentrations in severe forms of bipolar disorder.
BACKGROUND Bipolar disorder is a common psychiatric mood disorder that is defined by recurrent episodes of abnormally elevated mood and depression. Progressive structural brain changes in individuals with bipolar disorder have been suggested to be associated with defects in the secretion of neurotrophic factors. We sought to assess how the regulated secretory pathway in the brain is affected in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The New England journal of medicine
دوره 348 12 شماره
صفحات -
تاریخ انتشار 2003